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17 beta-hydroxysteroid dehydrogenase-8 (estradiol 17-beta-dehydrogenase 8, 17-beta-HSD 8, protein Ke6, Ke-6, HSD17B8, FABGL, HKE6, RING2, D6S2245E)
Function:
1) estrogens biosynthesis
2) uses estradiol as its preferred substrate
estradiol-17-beta + NAD(P)(+) estrone + NADPH
Expression:
- expressed in liver, pancreas > skeletal muscle, kidney
General
17 beta-hydroxysteroid dehydrogenase (estradiol 17 beta-dehydrogenase, HSD17B1)
Properties
SIZE: MW = 27 kD
entity length = 261 aa
COMPARTMENT: smooth endoplasmic reticulum
MOTIF: cofactor-binding site [15-39]
COFACTOR-BOUND: NAD
binding site
SITE: 156-156
FOR-BINDING-OF: estradiol
tyrosine residue {Y169}
Database Correlations
OMIM 601417
UniProt Q92506
Pfam PF00106
ENZYME 1.1.1.62
References
UniProt :accession Q92506