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rifapentine (Priftin)
Indications:
- tuberculosis
- chemoprophylaxis for tuberculosis (latent tuberculosis)
Contraindications:
1) not approved for children < 12 years of age
2) ok for use in patients with HIV1 infection [3]
Dosage:
- weekly in combination with isoniazid (latent tuberculosis)
- 10-14 kg: 300 mg weekly
- 14-25 kg: 450 mg weekly
- 25-32 kg: 600 mg weekly
- 32-50 kg: 750 mg weekly
- > 50 kg: 900 mg weekly
Tabs: 150 mg
Pharmacokinetics:
- esterase hydrolysis with fecal elimination
Adverse effects:
1) urine, body secretions may turn orange
2) may discolor contact lenses
3) hepatitis
4) rash
5) dyspepsia
Drug interactions:
1) avoid use with antiretroviral protease inhibitors
2) induces cyt P450s CYP2C9 & CYP3A4
- may diminish levels of drugs metabolized by CYP2C9 & CYP3A4
Interactions
drug interactions
Related
cytochrome P450 3A4 (cytochrome P450 C3, nifedipine oxidase, P450-PCN1, NF-25, CYP3A4)
General
rifamycin (rifamycin SV, Rifocin, Aemcolo)
Properties
MISC-INFO: elimination route PLASMA
pregnancy-category C
Database Correlations
PUBCHEM correlations
References
- Prescriber's Letter 13(3): 2006
Cytochrome P450 drug interactions
Detail-Document#: 220233
(subscription needed) http://www.prescribersletter.com
- Schechter M et al.
Weekly rifapentine/isoniazid or daily rifampin/pyrazinamide
for latent tuberculosis in household contacts.
Am J Respir Crit Care Med 2006 Apr 15; 173:922-6.
PMID: 16474028
- Medical Knowledge Self Assessment Program (MKSAP) 17, 19.
American College of Physicians, Philadelphia 2015, 2021