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rifamycin (rifamycin SV, Rifocin, Aemcolo)
Occurrence:
- natural antibiotic of group of antibiotics produced by Streptpmyces mediterranei (Amycolatopsis mediterranei)
Pharmacology:
Indications:
- treatment of autoimmune disorders
- rheumatoid arthritis
- bacterial infections due to susceptible organisms
- mycobacterial infections
- tuberculosis
- pulmonary tuberculosis
- latent tuberculosis
- tuberculous meningitis
- leprosy
- brucellosis
- osteomyelitis
- anthrax
- cutaneous anthrax
- inhalation anthrax
- traveler's diarrhea (Aemcolo) [5]
- hepatic encephalopathy
Monitor:
- liver function tests & CBC monthly
Antimicrobial activity:
- Gram-positive & Gram-negative bacteria
- used against Mycobacterium sp. (especially M. tuberculosis) in association with other agents to overcome resistance
- Staphylococcus
- Neisseria meningitidis
- Escherichia coli
- Brucella
Mechanism of action:
- inhibits prokaryotic DNA-dependent RNA synthesis & protein synthesis
- blocks RNA-polymerase transcription initiation
Notes:
- rifampin & rifabutin are related
Interactions
drug interactions
Specific
rifabutin (Mycobutin)
rifampin; rifampicin (Rifadin, Rimactane)
rifapentine (Priftin)
rifaximin (Xifaxan, Fatroximin, Normix)
General
anti-tuberculous agent
heterocyclic compound, 3 rings
Database Correlations
PUBCHEM correlations
References
- PubChem: 6324616
- WD: Rifamycin
http://www.wrongdiagnosis.com/medical/rifamycin.htm
- Medic8: Rifamycin
http://www.medic8.com/medicines/Rifamycin.html
- Chen LF, Kaye D.
Current use for old antibacterial agents: polymyxins,
rifamycins, and aminoglycosides.
Infect Dis Clin North Am. 2009 Dec;23(4):1053-75,
PMID: 19909897
- FDA News Release. Noove 16, 2018
FDA approves new drug to treat travelers' diarrhea.
https://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm626121.htm