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Rickettsia infection; Rickettsia spotted fever
Includes tick-borne infections:
1) Rocky Mountain spotted fever
2) ehrlichiosis
3) anaplasmosis
4) tick typhus
Clinical manifestations:
- presenting symptoms often non-specific
- fever
- headache
- malaise
- myalgia
- arthralgia
- conjunctivitis
- pharyngitis
- maculopapular rash, vesicular rash, or petechial rash develops 3-5 days after presentation [1]
Laboratory:
- Rickettsia antibody in serum
- Rickettsia RNA
Differential diagnosis:
- eschar & rash are characteristic of rickettsial infections
Management:
- doxycycline for 7-10 days is the treatment of choice
- no vaccine is available
Specific
anaplasmosis
Bartonella infection
ehrlichiosis
Q fever; Coxiella burnetii infection
rickettsial spotted fever; tick typhus
General
Rickettsiaceae infection
References
- Medical Knowledge Self Assessment Program (MKSAP) 15, 16, 17, 18, 19.
American College of Physicians, Philadelphia 2009, 2012, 2015, 2018, 2021.
- Parola P, Paddock CD, Raoult D.
Tick-borne rickettsioses around the world: emerging diseases
challenging old concepts.
Clin Microbiol Rev. 2005 Oct;18(4):719-56.
PMID: 16223955
- Parola P, Paddock CD, Socolovschi C et al
Update on tick-borne rickettsioses around the world: a
geographic approach.
Clin Microbiol Rev. 2013 Oct;26(4):657-702. Review.
PMID: 24092850 Free PMC Article
- Biggs HM, Behravesh CB, Bradley KK et al
Diagnosis and Management of Tickborne Rickettsial Diseases:
Rocky Mountain Spotted Fever and Other Spotted Fever Group
Rickettsioses, Ehrlichioses, and Anaplasmosis - United States.
A Practical Guide for Health Care and Public Health
Professionals.
MMWR Recomm Rep 2016;65(No. RR-2):1-44
PMID: 27172113
http://www.cdc.gov/mmwr/volumes/65/rr/rr6502a1.htm