protein RIC-3 (RIC3)

Function: - promotes functional expression of homomeric alpha-7 & alpha-8 nicotinic acetylcholine receptors at cell surface - may promote functional expression of homomeric serotoninergic 5-HT3 receptors, & of heteromeric acetylcholine receptors alpha-3/beta-2, alpha-3/beta-4, alpha-4/beta-2 & alpha-4/beta-4 - interacts with CHRNA7, CHRNA3, CHRNA4, CHRNB2, CHRNB4 & HTR3A Structure: belongs to the ric-3 family Compartment: - isoform 1: endoplasmic reticulum membrane - isoform 2: endoplasmic reticulum membrane, Golgi membrane Alternative splicing: named isoforms=5 Expression: - broadly expressed, with high levels in muscle, brain & heart Pathology: - overexpressed in brains from patients with bipolar disease or schizophrenia

Properties

SIZE: entity length = 369 aa MW = 41 kD COMPARTMENT: cellular membrane MOTIF: signal sequence {1-28} glycine-rich region {81-94} transmembrane domain {96-116} coiled coil {140-169} glutamate-rich region {269-272} MOTIF: glutamate residue (SEVERAL)

References

UniProt :accession Q7Z5B4