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rhoG proto-oncogene protein, G25K, Gp protein or CDC42Hs
Function:
- growth-related protein
- p21rho-G has relatively high intrinsic GTPase activity
- dbl-protein facilitates ras GAP activity of p21rhoG
- required for the formation of membrane ruffles during macropinocytosis
- required for the formation of cup-like structures during trans-endothelial migration of leukocytes.
- interacts with SGEF
Structure: belongs to the small GTPase superfamily, Rho family
Compartment:
- cell membrane; lipid-anchor; cytoplasmic side (putative)
Pathology:
- in case of Salmonella enteritidis infection, activated by SopB & SGEF, which induces cytoskeleton rearrangements & promotes bacterial entry
General
rho subfamily protein
Properties
SIZE: MW = 21 kD
COMPARTMENT: plasma membrane
CELL: unspecified cell type
WITHIN: brain
ORGANISM: mammal
MOTIF: GTP-binding site
SITE: 10-17
GTP-binding site
SITE: 57-61
GTP-binding site
SITE: 115-118
CaaX motif
SITE: C-TERMINUS
QUALITIES: AAX-TRUNCATED
CARBOXYMETHYLATED
EFFECTOR-BOUND: GERANYLGERANYL{C-20}
BOUND-VIA: cysteine residue
Database Correlations
OMIM 179505
UniProt P84095
Pfam PF00071
Entrez Gene 391
Kegg hsa:391
References
- UniProt :accession P84095
- Seabra MC, Reiss Y, Casey PJ, Brown MS, Goldstein JL.
Protein farnesyltransferase and geranylgeranyltransferase share
a common alpha subunit.
Cell. 1991 May 3;65(3):429-34.
PMID: 201897511
- Kahn RA, Der CJ, Bokoch GM.
The ras superfamily of GTP-binding proteins: guidelines on
nomenclature.
FASEB J. 1992 May;6(8):2512-3.
PMID: 1592203
- Manser E, Leung T, Salihuddin H, Zhao ZS, Lim L.
A brain serine/threonine protein kinase activated by Cdc42
and Rac1.
Nature. 1994 Jan 6;367(6458):40-6.
PMID: 8107774
- Entrez Gene :accession 391
Component-of
guaifenesin/p21rho g/phenylephrine