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rho subfamily protein

Function: - regulation of cytoskeleton assembly (putative) - essential for serum-induced formation of focal adhesions & stress fibers - activates PI-3-kinase & PIP-5-kinase (putative) - may induce tyrosine kinase activity [3] - role in integrin-mediated cell surface adhesion & proliferation, thus in synapse formation & neuronal plasticity [4] Pathology: - exoenzyme C3 of C. botulinum ADP-ribosylates rho & disrupts actin microfilaments

Related

arh proto-oncogene or rho proto-oncogene

Specific

CDC42 homolog; cell division control protein 42 homolog; G25K GTP-binding protein (CDC42) rac proto-oncogene protein (p21rac) Rho-related GTP-binding protein RhoE; Rho family GTPase 3; Rnd3; Rho8; memB protein (RND3, ARHE, RHO8, RHOE) Rho-related GTP-binding protein RhoF; Rho family GTPase Rif; Rho in filopodia (RHOF, ARHF, RIF) rho6 protein (Rho-related GTP-binding protein Rho6, Rnd1) rhoA proto-oncogene protein; transforming protein RhoA; H12 (RHOA, ARH12, ARHA, RHO12) rhoB proto-oncogene protein; Rho-related GTP-binding protein RhoB; rho protein H6 (RHOB, ARH6, ARHB) rhoC proto-oncogene protein; Rho-related GTP-binding protein RhoC; rho protein H9 (RHOC, ARH9, ARHC) rhoD protein; Rho-related GTP-binding protein RhoD; Rho-related protein HP1; RhoHP1 (RHOD, ARHD) rhoG proto-oncogene protein, G25K, Gp protein or CDC42Hs RhoH protein; Rho-related GTP-binding protein RhoH; GTP-binding protein TTF; translocation three-four (RhoH, ARHH, TTF) rhoI protein; GTP-binding protein Di-Ras3; distinct subgroup of the Ras family member 3; Rho-related GTP-binding protein RhoI (DIRAS3, ARHI, NOEY2, RHOI) rhoN protein (Rho-related GTP-binding protein RhoN, Rho7, Rnd2)

General

prenyl protein proto oncogene protein ras superfamily protein

Properties

SIZE: MW = 20-29 kD COMPARTMENT: cellular compartment CELL: unspecified cell type ORGANISM: mammal MOTIF: active site P-loop FOR-BINDING-OF: guanosine triphosphate guanosine diphosphate allosteric site CaaX motif SITE: C-TERMINUS QUALITIES: AAX-TRUNCATED CARBOXYMETHYLATED EFFECTOR-BOUND: GERANYLGERANYL{C-20} BOUND-VIA: cysteine residue

References

  1. Bourne HR et al, The GTPase superfamily: a conserved switch for diverse cell functions Nature 348:125 1990 PMID: 2122258
  2. Kahn RA, Der CJ, Bokoch GM. The ras superfamily of GTP-binding proteins: guidelines on nomenclature. FASEB J. 1992 May;6(8):2512-3. PMID: 1592203
  3. Clark EA & Brugge JS Integrins and signal transduction pathways: the road taken. Science 268:233 1995 PMID: 7716514
  4. Rampon C, Jiang CH, Dong H, Tang YP, Lockhart DJ, Schultz PG, Tsien JZ, Hu Y. Effects of environmental enrichment on gene expression in the brain. Proc Natl Acad Sci U S A. 2000 Nov 7;97(23):12880-4. PMID: 11070096