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rho-associated kinase ROCK
two isoforms: ROCK1 & ROCK2.
Function:
- downstream effector of Rho proteins
- role in cytokeletal assembly & reorganization
- both ROCK1 & ROCK2 negativel regulate of VEGF-induced angiogenic endothelial cell activation
Comparative biology:
- IL-17 facilitates Rho-kinase dependent inhibitory phosphorylation of endothelial nitric oxide synthase in mice reducing nitric oxide production in cerebral endothelial cells, inhibiting resting cerebral perfusion & endothelial function, leading to cognitive impairment* [2]
* unclear if this is ROCK1, ROCK2 or both [2]
Specific
rho-associated coiled-coil-containing protein kinase 1; p160ROCK; ROK-beta; Rho-associated protein kinase 1 (ROCK1)
Rho-associated protein kinase 2; Rho kinase 2; Rho-associated, coiled-coil-containing protein kinase 2; p164 ROCK-2 (ROCK2, KIAA0619)
General
serine/threonine kinase
Properties
STATE: active state
MOTIF: S/T phosphorylation site
kinase domain
MOTIF: ATP-binding site
NAME: ATP-binding site
References
- Zhao Z, Rivkees SA.
Rho-associated kinases play a role in endocardial cell
differentiation and migration.
Dev Biol. 2004 Nov 1;275(1):183-91.
PMID: 15464581
- Faraco G, Brea D, Garcia-Bonilla L.
Dietary salt promotes neurovascular and cognitive dysfunction
through a gut-initiated TH17 response.
Nature Neuroscience. Jan 15, 2018
PMID: 29335605
https://www.nature.com/articles/s41593-017-0059-z