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rheumatoid factor (RF)
Etiology:
1) disorders most likely to have high titers
a) rheumatoid arthritis (80%, 50% in elderly)
-> often negative in early phases of RA
b) Sjogren's syndrome
c) mixed cryoglobulinemia
d) subacute bacterial endocarditis
2) disorders with low titers
a) systemic lupus erythematosus
b) scleroderma (systemic sclerosis)
c) mixed connective tissue disease
d) sarcoidosis
e) idiopathic pulmonary fibrosis
f) hypergammaglobulinemic purpura
g) asbestosis
h) malignancies
i) infectious mononucleosis
j) influenza
k) chronic active hepatitis (B & C)
l) vaccinations
m) tuberculosis
n) syphilis
o) Brucellosis
p) Leprosy
q) Salmonellosis
r) Malaria
s) Kala-azar
t) Schistosomiasis
u) Filariasis
v) Trypanosomiasis
w) rubella
Related
rheumatoid arthritis (RA)
rheumatoid factor in serum
General
autoantibody
References
- Clinical Diagnosis & Management by Laboratory Methods,
19th edition, J.B. Henry (ed), W.B. Saunders Co.,
Philadelphia, PA. 1996, pg 471, 475, 1019
- Mayo Internal Medicine Board Review, 1998-99, Prakash UBS (ed)
Lippincott-Raven, Philadelphia, 1998, pg 826
- Medical Knowledge Self Assessment Program (MKSAP) 11, 17.
American College of Physicians, Philadelphia 1998, 2015
- Nielsen SF et al.
Elevated rheumatoid factor and long term risk of rheumatoid
arthritis: A prospective cohort study.
BMJ 2012 Sep 6; 345:e5244
PMID: 22956589
- Simard JF and Holmqvist M.
Rheumatoid factor positivity in the general population.
BMJ 2012 Sep 6; 345:e5841
PMID: 22956591
Component-of
arthritis panel
rheumatoid factor & cyclic citrullinated peptide IgG