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rheumatologic disease

Indefinite term applied to diseases with pain or other symptoms of articular origin or related to other elements of the musculoskeletal system. A related or similar term in use is connective tissue disorder. An alternative definition is autoinflammatory disease as many if not all rheumatologic diseases are associated with inflammation not due to infection or other exogenous etiology. Disorders resulting from trauma or surgical interventions are generally considered orthopedic disorders. Epidemiology: - see specific rheumatologic disease - see ref [3] Genetics: - see specific rheumatologic disease - see ref [5] Laboratory: - see specific rheumatologic disease - see ref [7] Clinical manifestations: - see specific rheumatologic disease - see ref [6,8] Differential diagnosis: - scurvy [12] Management: - instruments such as the Disease Activity Score or the Health Assessment Questionnaire are used for - assessment of disease activity & progression - overall functional assessment [2] - non-pharmacologic measures - physical therapy - occupational therapy - surgery - weight reduction - psychosocial support - self-management programs [2] - statins of questionable value - raw data suggests harm - massaged data suggests benefit [10] - long-term glucocorticoids <= 5 mg/day of prednisone do not seem to adversely affect bone mineral density [13]

Related

autoantibodies in rheumatologic disease autoimmune disease dermatologic manifestations of rheumatologic disease hereditary periodic fever syndrome; periodic fevers; recurrent fever syndrome; familial autoinflammatory disease radiographic findings of rheumatologic disease rheumatologic manifestations of systemic disease

Specific

HIV1/AIDS-associated rheumatologic disorder palindromic rheumatism; Hench-Rosenberg syndrome; intermittent hydrarthrosis rheumatologic complication of diabetes mellitus rheumatologic disorders in pregnancy rheumatologic disorders in the elderly

General

connective tissue disease; soft tissue disease

References

  1. Stedman's Medical Dictionary 27th ed, Williams & Wilkins, Baltimore, 1999
  2. Medical Knowledge Self Assessment Program (MKSAP) 16, 18, 19. American College of Physicians, Philadelphia 2012. 2018, 2022.
  3. Helmick CG, Felson DT, Lawrence RC et al Estimates of the prevalence of arthritis and other rheumatic conditions in the United States. Part I. Arthritis Rheum. 2008 Jan;58(1):15-25 PMID: 18163481 - Lawrence RC, Felson DT, Helmick CG et al Estimates of the prevalence of arthritis and other rheumatic conditions in the United States. Part II. Arthritis Rheum. 2008 Jan;58(1):26-35. PMID: 18163497
  4. Franco-Paredes C, Diaz-Borjon A, Senger MA et al The ever-expanding association between rheumatologic diseases and tuberculosis. Am J Med. 2006 Jun;119(6):470-7. PMID: 16750957
  5. Yao Q, Furst DE. Autoinflammatory diseases: an update of clinical and genetic aspects. Rheumatology (Oxford). 2008 Jul;47(7):946-51 PMID: 18388145
  6. Clarke JT, Werth VP. Rheumatic manifestations of skin disease. Curr Opin Rheumatol. 2010 Jan;22(1):78-84 PMID: 19851110
  7. Colglazier CL, Sutej PG. Laboratory testing in the rheumatic diseases: a practical review. South Med J. 2005 Feb;98(2):185-91. PMID: 15759949
  8. Kitas G, Banks MJ, Bacon PA. Cardiac involvement in rheumatoid disease. Clin Med. 2001 Jan-Feb;1(1):18-21. PMID: 11358070
  9. Kelly C, Iqbal K, Iman-Gutierrez L, Evans P, Manchegowda K. Lung involvement in inflammatory rheumatic diseases. Best Pract Res Clin Rheumatol. 2016 Oct;30(5):870-888. Review. PMID: 27964793
  10. Jorge AM, Lu N, Keller SF, Rai SK, Zhang Y, Choi HK. The effect of statin use on mortality in systemic autoimmune rheumatic diseases. J Rheumatol. 2018 Dec;45(12):1689-1695. PMID: 30173155 http://www.jrheum.org/content/45/12/1689
  11. Conti F, Rezai S, Valesini G. Vaccination and autoimmune rheumatic diseases. Autoimmun Rev 2008 Aug 14; 8:124 PMID: 18700175
  12. Perkins A, Sontheimer C, Otjen JP, Shenoi S. Scurvy masquerading as juvenile idiopathic arthritis or vasculitis with elevated inflammatory markers: A case series. J Pediatr 2019 Dec 13; S0022-3476(19)31470-2 PMID: 31843213
  13. Wiebe E, Huscher D, Schaumburg D, et al. Optimising both disease control and glucocorticoid dosing is essential for bone protection in patients with rheumatic disease. Ann Rheum Dis. Published online ahead of print June 9, 2022. PMID: 35680387