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blood group Rh(D) polypeptide; rhesus D antigen; RHXIII; Rh polypeptide 2; RhPII; CD240D (RHD)
Function:
- may be part of an oligomeric complex which is likely to have a transport or channel function in the erythrocyte membrane
Structure:
- belongs to the ammonium transporter (TC 2.A.49) family, Rh subfamily
Compartment: membrane
Alternative splicing: named isoforms=3
Expression:
- restricted to tissues or cell lines expressing erythroid characteristics
Polymorphism:
- RHD & RHCE are responsible for the Rh blood group system
- the molecular basis of the tar=Rh40 blood group antigen is a polymorphism in position 110
Related
Rh isoimmunization (Rh disease)
RhD antibody in serum
RHD gene mutation
RHD+RHC gene mutations
Rhesus blood group cluster
Rhesus D antigen negative
Rhesus D antigen positive
General
blood group antigen
cluster-of-differentiation antigen; cluster designation antigen; CD antigen
transmembrane 11 protein
Properties
SIZE: entity length = 417 aa
MW = 45 kD
COMPARTMENT: plasma membrane
MOTIF: transmembrane domain {12-32}
transmembrane domain {44-64}
transmembrane domain {77-97}
transmembrane domain {107-127}
transmembrane domain {130-150}
transmembrane domain {167-187}
transmembrane domain {203-223}
transmembrane domain {238-258}
transmembrane domain {287-307}
transmembrane domain {334-354}
transmembrane domain {358-378}
Database Correlations
OMIM 111680
UniProt Q02161
Pfam PF00909
Entrez Gene 6007
Kegg hsa:6007
References
- UniProt :accession Q02161
- dbRBC/BGMUT; Note: Blood group antigen gene mutation database
http://www.ncbi.nlm.nih.gov/gv/mhc/xslcgi.cgi?cmd=bgmut/systems_info&system=rh
- GeneReviews
https://www.genecards.org/cgi-bin/carddisp.pl?gene=RHD