regulator of G-protein signaling 9 (RGS9)

Function: - inhibits signal transduction by increasing GTPase activity of G-alpha subunits thus increasing the amount of inactive GDP-bound form - binds to Gt-alpha - role in phototransduction recovery phase (putative) - retinal isoform 3 is light-dependent phosphorylated at Ser-478 - phosphorylation is decreased by light exposition - heterodimer with Gbeta5 - interacts with RGS9BP, regulating the subcellular location RGS9/Gbeta5 heterodimer - component of the RGS9-1-Gbeta5 complex composed of isoform 3 of RGS9 (RGS9-1), Gbeta5 (GNB5) & RGS9BP (probable) Structure: - in photoreceptor cells the DEP domain is essential for targeting RGS9 to the outer rod segments - contains 1 DEP domain - contains 1 G protein gamma domain - contains 1 RGS domain Compartment: - isoform 3: membrane; peripheral membrane protein. - isoform 3 is targeted to the membrane via its interaction with RGS9BP (putative) Alternative splicing: named isoforms=5 Expression: - highly expressed in the caudate & putamen, - lower levels found in the hypothalamus & nucleus accumbens - very low levels in cerebellum - not expressed in globus pallidus or cingulate cortex - isoform 2 is expressed predominantly in pineal gland & retina - isoform 3 is expressed in retina (abundant in photoreceptors) Pathology: - defects in RGS9 are a cause of prolonged electroretinal response suppression (bradyopsia)

Properties

SIZE: entity length = 674 aa MW = 77 kD MOTIF: DEP domain {30-105} G protein gamma {219-280} RGS {298-413}

Database Correlations

OMIM correlations MORBIDMAP 604067 UniProt O75916 PFAM correlations Entrez Gene 8787 Kegg hsa:8787

References

UniProt :accession O75916