regulator of G-protein signaling 7 (RGS7)

Function: - inhibits signal transduction by increasing GTPase activity of G-alpha subunits thus increasing the amount of inactive GDP-bound form - activity on Go-alpha is specifically enhanced by the RGS7/GNG5 dimer - may play a role in synaptic vesicle exocytosis - may play a role in regulation of neuronal excitability & cellular responses to short-lived stimulations - palmitoylated (putative) - phosphorylation & subsequent interaction with 14-3-3 proteins inhibits GAP activity - heterodimer with GNG5 - interacts with RGS7BP, regulating subcellular location of the RGS7/GNG5 heterodimer - interacts with 14-3-3 protein Tau & SNAPIN Structure: - contains 1 DEP domain - contains 1 G protein gamma domain - contains 1 RGS domain Alternative splicing: named isoforms=5

General

phosphoprotein regulator of G-protein signaling

Properties

SIZE: entity length = 495 aa MW = 58 kD MOTIF: DEP domain {37-112} Ser phosphorylation site {S229} G protein gamma {255-316} RGS {333-448} MOTIF: Ser phosphorylation site {S434}

Database Correlations

OMIM 602517 UniProt P49802 PFAM correlations Entrez Gene 6000 Kegg hsa:6000

References

UniProt :accession P49802