Search
regulator of G-protein signaling 6; S914 (RGS6)
Function:
- inhibits signal transduction by increasing GTPase activity of Gp-alpha subunits thus increasing the amount of inactive GDP-bound form
- activity on Go-alpha is specifically enhanced by the RGS6/Gbeta5 dimer
- heterodimer with Gbeta5
- interacts with RGS7BP, regulating subcellular location of the RGS6/Gbeta5 dimer (putative)
Structure:
- contains 1 DEP domain
- contains 1 G protein gamma domain
- contains 1 RGS domain
Compartment:
- cytoplasm, peripheral membrane
Alternative splicing: named isoforms=11
General
regulator of G-protein signaling
Properties
SIZE: entity length = 472 aa
MW = 54 kD
COMPARTMENT: cytoplasm
MOTIF: DEP domain {40-115}
G protein gamma {261-330}
RGS {336-441}
Database Correlations
OMIM 603894
UniProt P49758
PFAM correlations
Entrez Gene 9628
Kegg hsa:9628
References
UniProt :accession P49758