regulator of G-protein signaling 4; RGP4 (RGS4)

Function: - inhibits signal transduction by increasing GTPase activity of G-alpha subunits thus increasing the amount of inactive GDP-bound form - activity on Gz-alpha is inhibited by phosphorylation - activity on Gz-alpha & Gi-alpha-1 is inhibited by palmitoylation (of G-protein) - palmitoylated on Cys-2 &/or Cys-12 - phosphorylated by cyclic GMP-dependent protein kinase Structure: contains 1 RGS domain Pathology: - genetic variation in RGS4 is associated with susceptibility to schizophrenia type 9

General

membrane protein regulator of G-protein signaling

Properties

SIZE: entity length = 205 aa MW = 23 kD COMPARTMENT: cellular membrane MOTIF: cysteine residue {C2} MODIFICATION: palmitate COMPARTMENT: membrane cysteine residue {C12} MODIFICATION: palmitate COMPARTMENT: membrane membrane region RGS {62-178} MOTIF: cysteine residue {C95} MODIFICATION: palmitate COMPARTMENT: membrane

Database Correlations

OMIM correlations UniProt P49798 Pfam PF00615 Entrez Gene 5999

References

UniProt :accession P49798