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regulator of G-protein signaling 2; RGS2; G0/G1 switch regulatory protein 8; cell growth-inhibiting gene 31 protein (RGS2, G0S8, GIG31)
Function:
- inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form
- may play a role in leukemogenesis
- phosphorylated by protein kinase C
Structure: contains 1 RGS domain
Expression:
- expressed in acute myelogenous leukemia (AML) & in acute lymphoblastic leukemia (ALL)
General
phosphoprotein
Properties
SIZE: entity length = 211 aa
MW = 24 kD
MOTIF: phosphorylation site
RGS {83-199}
Database Correlations
OMIM 600861
UniProt P41220
Pfam PF00615
Entrez Gene 5997
Kegg hsa:5997
References
UniProt :accession P41220