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regulator of G-protein signaling 11 (RGS11)
Function:
- inhibits signal transduction by increasing GTPase activity of G-alpha subunits increasing the amount of inactive GDP-bound form
- heterodimer with Gbeta5
- interacts with RGS7BP, regulating subcellular location of the RGS11/Gbeta5 heterodimer (putative)
Structure:
- contains 1 DEP domain
- contains 1 G protein gamma domain
- contains 1 RGS domain
Alternative splicing: named isoforms=2
General
regulator of G-protein signaling
Properties
SIZE: entity length = 467 aa
MW = 53 kD
MOTIF: DEP domain {32-107}
G protein gamma {219-282}
RGS {299-414}
Database Correlations
OMIM 603895
UniProt O94810
PFAM correlations
Entrez Gene 8786
Kegg hsa:8786
References
UniProt :accession O94810