DNA polymerase zeta catalytic subunit (REV3L, POLZ REV3)

Function: - translesion DNA synthesis (putative) - interacts with REV7 - component of DNA polymerase zeta Structure: - homolog of S. cerevisiae REV3 - Its C-terminal part could serve as the catalytic domain during nucleotide polymerization - its N-terminal part could provide sites for protein-protein interactions with other factors during translesion DNA synthesis - belongs to the DNA polymerase type-B family Compartment: nucleus (putative) Alternative splicing: named isoforms=2 Expression: ubiquitously expressed

General

phosphoprotein protein subunit zinc finger protein

Properties

SIZE: entity length = 3130 aa MW = 353 kD COMPARTMENT: cell nucleus MOTIF: Thr phosphorylation site {T582} Ser phosphorylation site {S583} Thr phosphorylation site {T2298} Ser phosphorylation site {S2522} Zn finger C4-type SITE: 3042-3057 EFFECTOR-BOUND: Zn+2 Zn finger C4-type SITE: 3086-3104 EFFECTOR-BOUND: Zn+2

Database Correlations

OMIM 602776 UniProt O60673 PFAM correlations Kegg hsa:5980 ENZYME 2.7.7.7

References

UniProt :accession O60673