DNA repair protein REV1; alpha integrin-binding protein 80; AIBP80; Rev1-like terminal deoxycytidyl transferase (REV1, REV1L)

Function: - deoxycytidyl transferase - involved in DNA repair - transfers a dCMP residue from dCTP to the 3'-end of a DNA primer in a template-dependent reaction - may assist in the first step in the bypass of abasic lesions by insertion of a nucleotide opposite the lesion - required for normal induction of mutations by physical & chemical agents - interacts with the DNA polymerase zeta - interaction with MAD2L2 is direct & requires that REV3L is in its closed conformation - interacts with POLH, POLI & POLK - may bind ITGA3 Structure: - monomer - the C-terminal domain is necessary for protein interactions - belongs to the DNA polymerase type-Y family - contains 1 BRCT domain - contains 1 umuC domain Compartment: nucleus (probable) Alternative splicing: named isoforms=3 Expression: ubiquitous

General

DNA nucleotidyltransferase phosphoprotein

Properties

SIZE: entity length = 1251 aa MW = 138 kD COMPARTMENT: cell nucleus MOTIF: BRCA1 C-terminal (BRCT) motif SITE: 44-131 target DNA interaction {352-362} MOTIF: binding site SITE: 357-357 FOR-BINDING-OF: dCTP UmuC {419-653} MOTIF: Mg+2-binding site SITE: 423-423 binding site SITE: 522-522 FOR-BINDING-OF: dCTP Mg+2-binding site SITE: 570-570 binding site SITE: 570-570 FOR-BINDING-OF: dCTP Mg+2-binding site SITE: 571-571 target DNA interaction {653-656} target DNA interaction {709-717} lysine residue {770} threonine residue {783} nuclear translocation signal {1071-1078} Ser phosphorylation site {S1082} Ser phosphorylation site {S1108} DNA polymerase zeta interaction {1150-1249}

Database Correlations

OMIM 606134 UniProt Q9UBZ9 PFAM correlations Entrez Gene 51455 Kegg hsa:51455

References

UniProt :accession Q9UBZ9