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antiretroviral protease inhibitor
Class of pharmceutical agents used for treatment of AIDS/HIV
Dosage:
- almost always administered with ritonavir
Adverse effects:
1) hyperlipidemia:
a) increased cholesterol & triglycerides
b) protease inhibitor lipodystrophy
2) hyperglycemia
3) osteoporosis
4) hyperprolactinemia [3]
Drug interactions:
1) HMG CoA reductase inhibitors
a) lovastatin & simvastatin metabolism may be slowed by protease inhibitors
b) pravastatin (Pravachol) or atorvastatin (Lipitor) are recommended for patients taking antiretroviral protease inhibitors
2) nicotinic acid (niacin): additive effect on insulin-resistance & hyperglycemia
3) ritonavir increases antiretroviral protease inhibitor levels
- interaction used for therapeutic effect
4) antiretroviral protease inhibitors metabolized by cyt P450 3A4 (saquinavir ...) may increase in plasma when coadministered with inhibitorss of cyt P450 3A4 (diatiazem, verapamil ...)
Interactions
drug interactions
drug adverse effects (more general classes)
Related
Acquired Immuno-Deficiency Syndrome (HIV infection stage 3, AIDS)
HIV1 protease inhibitor lipodystrophy
human immunodeficiency virus-1 (HIV-1)
Specific
amprenavir (Agenerase)
atazanavir (Reyataz, ATV/r)
darunavir (Prezista, DRV/r)
fosamprenavir (Lexiva)
indinavir (Crixivan)
lopinavir (Aluviran)
nelfinavir (Viracept)
ritonavir (Norvir, RTV)
saquinavir (Invirase, Fortovase)
tipranavir (Aptivus, TPV)
General
antiretroviral agent
antiviral protease inhibitor
Properties
INHIBITS: protease
References
- Prescriber's Letter 7(8):45 2000
- Prescriber's Letter 9(8):47 2002
- Medical Knowledge Self Assessment Program (MKSAP) 14, 16
American College of Physicians, Philadelphia 2006, 2012