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plasma retinol binding protein; PRBP; retinol binding protein 4 (RBP4, PRO2222)
Function:
- transports retinol from the liver to peripheral tissues
- in plasma, the RBP-retinol complex interacts with transthyretin, which prevents its loss by renal glomerular filtration
Structure:
- belongs to the calycin superfamily, lipocalin family
Compartment: secreted
Pathology:
1) defects are a cause of retinol-binding protein deficiency
2) RBP4 levels correlate with insulin resistance [2]; RBP4 may play role in insulin resistance [2]
Related
insulin resistance
retinol-binding protein deficiency
General
alpha globulin
lipocalin
retinol binding protein
Properties
SIZE: entity length = 201 aa
MW = 23 kD
COMPARTMENT: plasma
MOTIF: signal sequence {1-18}
cysteine residue {C22}
MODIFICATION: cysteine residue {C178}
cysteine residue {C88}
MODIFICATION: cysteine residue {C192}
cysteine residue {C138}
MODIFICATION: cysteine residue {C147}
cysteine residue {C147}
MODIFICATION: cysteine residue {C138}
cysteine residue {C178}
MODIFICATION: cysteine residue {C22}
cysteine residue {C192}
MODIFICATION: cysteine residue {C88}
MISC-INFO: lifetime <12 HOURS {1/2-LIFE}
Database Correlations
OMIM 180250
UniProt P02753
Pfam PF00061
Entrez Gene 5950
Kegg hsa:5950
References
- Tietz Fundamentals of Clinical Chemistry 3rd ed, WB
Saunders, 1987 pg 334
- Graham TE et al,
Retinol-binding protein 4 and insulin resistance in lean,
obese and diabetic subjects.
N Engl J Med 2006; 354:2552
PMID: 16775236
- UniProt :accession P02753
- Mutations of the RBP4 gene;
Retina International's Scientific Newsletter
http://www.retina-international.com/sci-news/rlbp4mut.htm
- Wikipedia; Retinol-binding protein 4
http://en.wikipedia.org/wiki/retinol_binding_protein_4