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RalBP1-associated Eps domain-containing protein 2 (RalBP1-interacting protein 2, partner of RalBP1, REPS2, POB1)
Function:
1) role in growth factor signaling through its influence on the Ral signaling pathway
2) interacts with DDEF1 & this complex can bind paxillin
3) may form a ternary complex with RALBP1 & DDEF1
4) interacts with RALBP1 & GRB2
5) binding to RALBP1 does not affect the Ral-binding activity of the latter
6) forms ternary complex with activated Ral & RALBP1
7) binds EPN1
8) EGF stimulates phosphorylation on Tyr & induces complex formation with EGF receptor via adapter protein, i.e. GRB2
Compartment: cytoplasm
Alternative splicing: named isoforms=2
Expression:
- expressed in cerebrum, cerebellum, lung, kidney, testis > kidney
Pathology:
- relatively highly expressed in androgen-dependent as compared with androgen-independent prostate cancer cell lines
- isoform 2 is down-regulated during progression of prostate cancer
General
other protein
Properties
SIZE: MW = 72 kD
entity length = 660 aa
COMPARTMENT: cytoplasm
MOTIF: alanine-rich region {3-76}
MOTIF: alanine residue (SEVERAL)
EH 1 {34-147}
EH 2 {282-373}
MOTIF: EF hand
SITE: 315-350
proline-rich region
SITE: 477-524
MOTIF: proline residue (SEVERAL)
interaction with RALBP1 {514-660}
MOTIF: interaction with DDEF1 {561-660}
coiled coil {601-657}
Database Correlations
OMIM 300317
UniProt Q8NFH8
Pfam PF00036
References
UniProt :accession Q8NFH8