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replication factor C subunit 2 (replication factor C 40 kD subunit, RF-C 40 kD subunit, RFC40, activator 1 40 kD subunit, A1 40 kD subunit, RFC2)
Function:
- one of 5 subunits of replication factor C
- binds ATP
- RFC2 interacts with PRKAR1A; interaction may be involved in cell survival
Structure: belongs to the activator 1 small subunits family
Compartment: nucleus (probable)
Alternative splicing: named isoforms=2
Pathology:
- haploinsufficiency of RFC2 may be the cause of certain cardiovascular & musculo-skeletal abnormalities observed in Williams-Beuren syndrome
General
protein subunit
Properties
SIZE: MW = 40-41 kD
MOTIF: ATP-binding site
NAME: ATP-binding site
Database Correlations
OMIM correlations
UniProt P35250
PFAM correlations
References
- Linn S
How many pols does it take to replicate nuclear DNA?
Cell 66:185 1991
PMID: 1855251
- UniProt :accession P35250
Component-of
CTF18-replication factor C