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replication factor C subunit 1 (replication factor C p140, replication factor C large subunit, RF-C 140 kD subunit, activator 1 140 kD subunit, activator 1 large subunit, A1 140 kD subunit, DNA-binding protein PO-GA, RFC1, RFC140)
Function:
- component of replication factor C
- RFC1 subunit binds to the primer-template junction
- binds the PO-B transcription element as well as other GA rich DNA sequences
- may play a role in DNA transcription regulation
- may play a role in DNA replication
- may play a role in DNA repair
- can bind single-stranded DNA or double-stranded DNA
- interacts with C-terminus of PCNA
- 5' phosphate residue is required for binding of the N-terminal DNA-binding domain to duplex DNA, suggesting a role in recognition of non-primer template DNA structures during replication &/or repair
- phosphorylated upon DNA damage, probably by ATM or ATR
Structure:
- belongs to the activator 1 140 kD subunit family
- contains 1 BRCT domain
Compartment: nucleus
Alternative splicing: named isoforms=2 Alternative use of an acceptor site
Expression:
- wide tissue distribution
- undetectable in placental tissue
General
DNA-binding protein
phosphoprotein
protein subunit
zinc finger protein
Properties
SIZE: entity length = 1148 aa
MW = 128 kD
COMPARTMENT: cell nucleus
MOTIF: Ser phosphorylation site {S69}
Ser phosphorylation site {S71}
Ser phosphorylation site {S73}
Ser phosphorylation site {S108}
Thr phosphorylation site {T110}
Ser phosphorylation site {S156}
Thr phosphorylation site {T161}
Ser phosphorylation site {S173}
Ser phosphorylation site {S190}
BRCA1 C-terminal (BRCT) motif
SITE: 402-492
ATP-binding site
NAME: ATP-binding site
SITE: 650-657
Zn finger C2HC-type
SITE: 749-766
EFFECTOR-BOUND: Zn+2
nuclear translocation signal {1120-1124}
Database Correlations
OMIM 102579
UniProt P35251
PFAM correlations
Kegg hsa:5981
References
- Linn S
How many pols does it take to replicate nuclear DNA?
Cell 66:185 1991
PMID: 1855251
- UniProt :accession P35251
Component-of
replication factor-C