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replication protein A 70 kD DNA-binding subunit; RP-A p70; replication factor A protein 1; RF-A protein 1; single-stranded DNA-binding protein (RPA1 REPA1 RPA70)
Function:
- subunit of replication factor A
- may be only DNA-binding subunit of replication factor A
- phosphorylated upon DNA damage, probably by ATM or ATR
- interacts with RIP & XPA.
- interacts with RPA4
Structure: belongs to the replication factor A protein 1 family
Compartment: nucleus
General
DNA-binding protein
protein subunit
Properties
SIZE: entity length = 616 aa
MW = 68 kD
COMPARTMENT: cell nucleus
MOTIF: Thr phosphorylation site {T180}
DNA-binding motif
SITE: 198-291
DNA-binding motif
SITE: 305-402
MOTIF: Ser phosphorylation site {S384}
Zn finger C4-type
SITE: 481-503
EFFECTOR-BOUND: Zn+2
Database Correlations
OMIM 179835
UniProt P27694
PFAM correlations
Entrez Gene 6117
Kegg hsa:6117
References
- UniProt :accession P27694
- NIEHS-SNPs
http://egp.gs.washington.edu/data/rpa1/
- Linn S
How many pols does it take to replicate nuclear DNA?
Cell 66:185 1991
PMID: 1855251
- de Laat WL et al,
Molecular mechonisms of nucleotide excision repair.
Genes & Dev 13:768-85, 1999
PMID: 10197977
Component-of
replication factor-A (RFA/RPA)