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renal cell carcinoma, clear cell type; clear cell (conventional) renal cell carcinoma

Epidemiology: 75-85% of renal carcinomas Pathology: - may arise from the proximal convoluted tubules within the renal cortex - propensity for vascular, rather than lymphatic, invasion [3] Microscopic Pathology: - clear cytoplasm, not necessarily all cells - variable nuclear pleomorphism - PAS/glycogen: positive - Hale's colloidal iron stain: negative - mucin: negative - oil red O (lipid): positive Genetics: - 3p-, vhl gene often deleted, - pbrm1 mutation in 50% of cases [2] - also see kidney cancer Clinical manifestations: - compared with other histologic types of RCC, more likely to be symptomatic [3] Laboratory: Immunocytochemistry: - low molecular weight cytokeratin: positive - high molecular weight cytokeratin: negative - epithelial membrane antigen: positive - vimentin: positive - carbonic anhydrase: positive - CD10: positive - RCC antibody: positive - placental alkaline phosphatase (PLAP): positive - carcinoembryonic antigen (CEA): negative - S100: negative - band 3 protein: negative - inhibin: negative Differential Diagnosis (histologic): - adrenal cortical carcinoma - urothelial carcinoma of renal pelvis - papillary renal cell carcinoma - chromophobe renal cell carcinoma - oncocytoma - melanoma

Interactions

disease interactions

Specific

renal cell carcinoma, clear cell type (hereditary renal cancer associated 1)

General

clear cell carcinoma renal cell carcinoma (hypernephroma, Grawitz tumor)

References

  1. Dabbs. Diagnostic Immunohistochemistry. Churchill-Livingstone, 2002. page 475
  2. Escudier B Medscape Oncology: Oct 10, 2014 Medscape Medical News from the: European Society for Medical Oncology (ESMO) Congress 2014 Refining Sunitinib Use Extends Survival in RCC http://www.medscape.com/viewarticle/832897
  3. Thomas S, Grimm L, Brady MP Renal Cell Carcinoma: Recognition and Follow-up. Medscape. April 18, 2016 http://reference.medscape.com/features/slideshow/renal-cell-carcinoma

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