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remitting seronegative synovitis with pitting edema
Etiology:
- part of the clinical spectrum of polymyalgia rheumatica
- associated with
- autoimmune disease
- neurodegenerative disease: Parkinson's disease
- paraneoplastic syndrome
Epidemiology:
- elderly patients, uncommon
Genetics: association with HLA-B27
Clinical manifestations:
- pain, swelling, stiffness & numbness in the hands
- inflammatory synovitis of the wrists & palmar tendon sheaths
- both flexor & extensor tendons affected
- can affect both hands & feet
- stiffness of the shoulders
- symptoms worse upon awakening, except for numbness
- numbness occurs more often at night
- no evidence of Raynaud's phenomenon
Management:
1) NSAIDs
2) glucocorticoids, treat as polymyalgia rheumatica
Related
polymyalgia rheumatica (PMR)
General
synovitis
References
- Medical Knowledge Self Assessment Program (MKSAP) 11, American
College of Physicians, Philadelphia 1998
- Geriatric Review Syllabus, 10th edition (GRS10)
Harper GM, Lyons WL, Potter JF (eds)
American Geriatrics Society, 2019