Search
transcription factor relB; I-rel (RELB)
Function:
- component of the NF-kappa-B RelB-p50 complex
- component of the NF-kappa-B RelB-p52 complex
- self-associates; the interaction seems to be transient & may prevent degradation allowing for heterodimer formation with p50 or p52
- NF-kappa-B heterodimeric RelB-p50 & RelB-p52 complexes are transcriptional activators
- RELB neither associates with DNA nor with RELA/p65 or REL
- stimulates promoter activity in the presence of NFKB2/p49
- interacts with NFKB1/p50, NFKB2/p52 & NFKB2/p100
- interacts with IKBNS
- phosphorylation at Thr-103 & Ser-573 is followed by proteasomal degradation (putative)
Structure:
- both N-terminal & C-terminal domains are required for transcriptional activation
- contains 1 RHD (Rel-like) domain
Compartment: nucleus
Expression: induced by mitogens
Note:
- originally thought to inhibit transcriptional activity of nuclear factor NF-kappa-B
General
phosphoprotein
rel protein family
Properties
SIZE: entity length = 579 aa
MW = 62 kD
COMPARTMENT: cell nucleus
MOTIF: leucine zipper
SITE: 40-68
FOR-BINDING-VIA: leucine zipper
Thr phosphorylation site {T103}
RHD {125-440}
MOTIF: nuclear translocation signal {433-438}
Ser phosphorylation site {S573}
Database Correlations
OMIM 604758
UniProt Q01201
PFAM correlations
Entrez Gene 5971
Kegg hsa:5971
References
- UniProt :accession Q01201
- Entrez Gene :accession 5971
- Atlas of genetics & cytogenetics in oncology & haematology
http://atlasgeneticsoncology.org/genes/RELBID324.html