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relaxin H2 (RLN2)
Function:
- ovarian hormone that acts with estrogen to produce dilatation of the birth canal in many mammals
- may be involved in remodeling of connective tissues during pregnancy, promoting growth of pubic ligaments & ripening of the cervix
- vasodilator involved in hemodynamic changes during pregnancy
Structure:
- heterodimer of a B chain & an A chain linked by two disulfide bonds
- belongs to the insulin family
Compartment: secreted
Alternative splicing: named isoforms=2
Expression:
- isoform 1: expressed in the ovary during pregnancy; also expressed in placenta, decidua & prostate
- isoform 2: relatively abundant in placenta, much lower abundance in the prostate gland; not detected in ovary
Pharmacology:
- serelaxin, a recombinant relaxin-2, showed some benefit for treatment of acute heart failure in a clinical trial [2]
General
relaxin
Properties
SIZE: entity length = 185 aa
MW = 21 kD
MOTIF: signal sequence {1-24}
cysteine residue {C35}
MODIFICATION: cysteine residue {C47}
cysteine residue {C47}
MODIFICATION: cysteine residue {C35}
cysteine residue {C171}
MODIFICATION: cysteine residue {C176}
cysteine residue {C176}
MODIFICATION: cysteine residue {C171}
Database Correlations
OMIM 179740
UniProt P04090
Pfam PF00049
Entrez Gene 6019
Kegg hsa:6019
References
- UniProt :accession P04090
- Teerlink JR et al.
Serelaxin, recombinant human relaxin-2, for treatment of
acute heart failure (RELAX-AHF): A randomised, placebo-
controlled trial.
Lancet 2012 Nov 7
PMID: 23141816
http://www.thelancet.com/journals/lancet/article/PIIS0140-6736(12)61855-8/fulltext
- Konstam MA.
RELAX-AHF: Rising from the doldrums in acute heart failure.
Lancet 2012 Nov 7
PMID: 23141815
http://www.thelancet.com/journals/lancet/article/PIIS0140-6736(12)61896-0/fulltext