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Lithostathine-1-beta; pancreatic stone protein 2; PSP-2; regenerating islet-derived protein 1-beta; REG-1-beta; regenerating protein 1 beta (REG1B, PSPS2, REGL)
Function:
- might act as an inhibitor of spontaneous Ca+2 carbonate precipitation
- may be associated with neuronal sprouting in brain, & with brain & pancreas regeneration
Structure:
- all O-linked glycans consist of gal-GlcNAc-gal-galNAc tetrasaccharide core & get elongated (microheterogeneity)
- contains 1 C-type lectin domain
Compartment: secreted
General
lithostathine
Properties
SIZE: entity length = 166 aa
MW = 19 kD
COMPARTMENT: extracellular compartment
MOTIF: signal sequence {1-22}
Thr glycosylation site {T27}
C-type lectin {34-164}
MOTIF: cysteine residue {C36}
MODIFICATION: cysteine residue {C47}
cysteine residue {C47}
MODIFICATION: cysteine residue {C36}
cysteine residue {C64}
MODIFICATION: cysteine residue {C162}
cysteine residue {C137}
MODIFICATION: cysteine residue {C154}
cysteine residue {C154}
MODIFICATION: cysteine residue {C137}
cysteine residue {C162}
MODIFICATION: cysteine residue {C64}
Database Correlations
OMIM 167771
UniProt P48304
Pfam PF00059
Entrez Gene 5968
Kegg hsa:5968
References
UniProt :accession P48304