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refractory anemia with ringed sideroblasts (RARS)

Epidemiology: 1) most common acquired form of sideroblastic anemia 2) 24% of cases of myelodysplastic syndrome Pathology: 1) circulating blasts < 1% 2) bone marrow blasts < 5% 3) > 15% ringed sideroblasts in marrow 4) no Auer rods Management: -> prognosis: a) 0-15% (mean 5%) transformation to acute leukemia (AML) b) survival 21-76 months (mean 49 months)

Interactions

disease interactions

General

myelodysplastic syndrome (MDS) sideroblastic anemia

References

  1. Medical Knowledge Self Assessment Program (MKSAP) 11, American College of Physicians, Philadelphia 1998
  2. Harrison's Principles of Internal Medicine, 14th ed. Fauci et al (eds), McGraw-Hill Inc. NY, 1998, pg 677-78
  3. http://pathy.med.nagoya-u.ac.jp/atlas/img/t5/img38.jpg
  4. http://pathy.med.nagoya-u.ac.jp/atlas/img/t8/img33.jpg