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red wine

Red wine may have especially potent cardioprotective effect against coronary artery disease. Resveratrol is thought to be a major beneficial component of red wine. Polyphenols in ethanol-free extracts of red wine diminished synthesis of endothelin-1 by cultured bovine endothelial cells. Red grape juice had a similar, but less potent effect. White & rose wines did not have this effect. The reduction in endothelin-1 was not mediated by antioxidant properties of the red-grape polyphenols. Lower all cause mortality in men 23-37% [2] Only alcoholic beverage associated with diminished risk of ischemic stroke. RR = 0.5 for > 10 g/day [3] red wine 1-7 servings per week may diminish risk of new-onset atrial fibrillation [5] red wine (150 mL daily) associated with increased HDL cholesterol (2.0 mg/dL), serum apolipoprotein1 (0.03 g/L) & cholesterol/HDL ratio (0.27), relative to mineral water Benefit of red wine may be due to other components in addition to resveratrol. [4]

Related

endothelin-1; preproendothelin-1; PPET1; contains: endothelin-1; ET-1; big endothelin-1 (EDN1)

General

wine

References

  1. Journal Watch 22(3):21, 2002 Corder et al, Nature 414: 863, 2001
  2. Netscape (09/20/04) cites American Journal of Clinical Nutrition
  3. Journal Watch 25(3):24, 2005 Mukamal KJ, Ascherio A, Mittleman MA, Conigrave KM, Camargo CA Jr, Kawachi I, Stampfer MJ, Willett WC, Rimm EB. Alcohol and risk for ischemic stroke in men: the role of drinking patterns and usual beverage. Ann Intern Med. 2005 Jan 4;142(1):11-9. Summary for patients in: Ann Intern Med. 2005 Jan 4;142(1):I24. PMID: 15630105
  4. Wang J, Ho L, Zhao Z, Seror I, Humala N, Dickstein DL, Thiyagarajan M, Percival SS, Talcott ST, Pasinetti GM. Moderate consumption of Cabernet Sauvignon attenuates Abeta neuropathology in a mouse model of Alzheimer's disease. FASEB J. 2006 Nov;20(13):2313-20. PMID: 17077308
  5. Stiles S New-AF Risk May Not Rise With Light Drinking, May Fall With Wine. Medscape - Aug 06, 2021 https://www.medscape.com/viewarticle/956211 - Tu SJ, Gallagher C, Elliott AD et al Risk Thresholds for Total and Beverage-Specific Alcohol Consumption and Incident Atrial Fibrillation. JACC: Clinical Electrophysiology. Available online 27 July 2021 PMID: 34330672 https://www.sciencedirect.com/science/article/abs/pii/S2405500X21005247
  6. Haas EA, Saad MJA, Santos A et al A red wine intervention does not modify plasma trimethylamine N-oxide but is associated with broad shifts in the plasma metabolome and gut microbiota composition. Am J Clin Nutr. 2022 Dec 19;116(6):1515-1529. PMID: 36205549 PMCID: PMC9761755 Free PMC article