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recombinant growth hormone-releasing hormone
Indications:
- growth hormone deficiency in the elderly
- may have beneficial effect on some cognitive measures in both normal elderly and those with amnestic MCI (mild cognitive impairment) [3]
Dosage: 14 ug/kg SC QHS (long-acting GHRH)
Monitor: IGF-1
Adverse effects:
1) increased prolactin
2) increased ACTH
Mechanism of action:
1) induces growth hormone release from pitituary somatotrophs
2) less effective than growth hormone
3) probably safe
4) may have beneficial effect on cognitive function
Notes:
- cost 2012: $50/injection
Related
appetite-regulating hormone; growth hormone secretagogue; growth hormone-releasing peptide; motilin-related peptide; M46 protein; contains: ghrelin-27, ghrelin-28, ghrelin, obestatin (GHRL, MTLRP, UNQ524/PRO1066)
growth hormone-releasing hormone receptor; GHRH receptor; GRF receptor; GRFR (GHRHR)
insulin-like growth factor-1; mechano growth factor; MGF; somatomedin-C (IGF1, IBP1)
somatotropin; growth hormone; somatropin (GH)
General
growth hormone-releasing hormone; somatotropin-releasing hormone,; somatocrinin; somatoliberin (GHRH)
recombinant protein; chimer
endocrine agent
References
- Solomon DH, in: UCLA Intensive Course in Geriatric Medicine &
Board Review, Marina Del Ray, CA, Sept 12-15, 2001
- Wikipedia, Growth hormone releasing hormone
http://en.wikipedia.org/wiki/GHRH
- Baker LD et al.
Effects of growth hormone-releasing hormone on cognitive
function in adults with mild cognitive impairment and
healthy older adults: Results of a controlled trial.
Arch Neurol 2012 Aug 6
http://archneur.jamanetwork.com/article.aspx?articleid=1306261