Search
recombinant antithrombin-III
see recombinant antithrombin
Contraindications:
- of no benefit in acutely ill patients [2]
Mechanism of action:
- most important serine protease inhibitor in plasma
- regulates the blood coagulation cascade
- inhibits thrombin, factor IXa, factor Xa & factor XIa
- inhibitory activity is greatly enhanced in the presence of heparin (heparin cofactor)
- anti-inflammatory properties [2
Interactions
drug adverse effects of antithrombotic agent(s)
General
antithrombin-III (ATIII, heparin cofactor, SERPINC1, AT3, PRO0309)
recombinant antithrombin (ATryn)
References
- UniProt :accession P01008
- Afshari A et al,
Antithrombin III in critically ill patients: Systematic
review with meta-analysis and trial sequential analysis.
BMJ 2007, 335:1248
PMID: 18037615
- antithrombin mutation db
http://www.med.ic.ac.uk/divisions/7/antithrombin/
- GeneReviews
http://www.genetests.org/query?gene=SERPINC1
- SHMPD;The Singapore human mutation andcpolymorphism database
http://shmpd.bii.a-star.edu.sg/gene.php?genestart=A&genename=SERPINC1
- Wikipedia; antithrombin entry
http://en.wikipedia.org/wiki/antithrombin