tyrosine kinase receptor (RTK)

After growth factor binding, RTKs dimerize, autophosphorylate & recruit adaptor proteins which interact with & activate various downstream effectors. * see figure

Specific

ALK tyrosine kinase receptor; anaplastic lymphoma kinase; CD246 (ALK) angiopoietin-1 receptor; tyrosine-protein kinase receptor TIE-2; hTIE2; tyrosine-protein kinase receptor TEK; tunica interna endothelial cell kinase; p140 TEK; CD202b (TEK, TIE2) c-kit protein; mast/stem cell growth factor receptor; SCFR; proto-oncogene tyrosine-protein kinase Kit; c-kit; CD117 (KIT) discoidin domain-containing receptor 2; discoidin domain receptor 2; receptor protein-tyrosine kinase TKT; tyrosine-protein kinase TYRO10; neurotrophic tyrosine kinase, receptor-related 3; CD167 antigen-like family member B; CD167b (DDR2, NTRKR3, TKT, TYRO10) EGF receptor family protein or erbB proto-oncogene protein elk receptor or Cek5 receptor eph family receptor epithelial discoidin domain-containing receptor 1; epithelial discoidin domain receptor 1; tyrosine kinase DDR; discoidin receptor tyrosine kinase; tyrosine-protein kinase CAK; cell adhesion kinase; TRK E; protein-tyrosine kinase RTK 6; HGK2; CD167 antigen-like family member A; CD167a (DDR1, CAK, EDDR1, NEP, NTRK4, PTK3A, RTK6, TRKE) eyk proto-oncogene receptor tyrosine kinase (chicken) fetal liver kinase-2 (flk-2) fibroblast growth factor [FGF] receptor FL cytokine receptor; tyrosine-protein kinase receptor FLT3; stem cell tyrosine kinase 1; STK-1; CD135 (FLT3, STK1) fms receptor hepatocyte growth factor receptor; HGF receptor; scatter factor receptor; SF receptor; HGF/SF receptor; Met proto-oncogene tyrosine kinase; c-Met (MET) insulin receptor-related protein; IR-related receptor; contains: insulin receptor-related protein alpha chain & insulin receptor-related protein beta chain (INSRR, IRR) insulin receptor; IR; (INSR) insulin-like growth factor [IGF]-1 receptor (somatomedin-C receptor, CD221, IGF1R) insulin-like growth factor [IGF]-2 receptor (CD222, somatomedin MSA receptor, cation-independent mannose-6-phosphate receptor, MPR 300, CI-MPR, M6PR, MPRI, IGF2R) Leukocyte tyrosine kinase receptor; protein tyrosine kinase 1 (LTK, TYK1) macrophage-stimulating protein receptor; MSP receptor; p185-Ron; CDw136; CD136 (MST1R, PTK8, RON) muscle, skeletal receptor tyrosine protein kinase(muscle-specific tyrosine protein kinase receptor, MuSK) neuroepithelial tyrosine kinase or protein tyrosine kinase-3 platelet-derived growth factor [PDGF] receptor preproinsulin receptor; IR; CD220; contains: insulin receptor subunit alpha, insulin receptor subunit beta (INSR) proto-oncogene tyrosine-protein kinase MER; C-mer; receptor tyrosine kinase MerTK (MERTK, MER) proto-oncogene tyrosine-protein kinase receptor ret; C-ret; (RET, CDHF12) proto-oncogene tyrosine-protein kinase ROS; c-ros protein; p53ros; mcf3 tyrosine kinase receptor; c-ros-1 (ROS1) RON protein or macrophage stimulating 1 receptor (MST1R) sea proto-oncogene protein tropomyosin receptor kinase (trk) proto-oncogene protein (NTRK) tyrosine-protein kinase ITK/TSK; T-cell-specific kinase; tyrosine-protein kinase Lyk; kinase EMT (ITK, EMT, LYK) tyrosine-protein kinase receptor Tie-1 (TIE1, TIE) tyrosine-protein kinase receptor TYRO3; tyrosine-protein kinase RSE; tyrosine-protein kinase SKY; tyrosine-protein kinase DTK; tyrosine-protein kinase byk (TYRO3, BYK, DTK, RSE, SKY) tyrosine-protein kinase receptor UFO; AXL proto-oncogene protein (AXL, UFO) tyrosine-protein kinase RYK (RYK, JTK5A) tyrosine-protein kinase transmembrane receptor ROR1; neurotrophic tyrosine kinase, receptor-related 1 (ROR1, NTRKR1) tyrosine-protein kinase transmembrane receptor ROR2; neurotrophic tyrosine kinase, receptor-related 2 (ROR2, NTRKR2) vascular endothelial growth factor [VEGF] receptor

General

cell surface receptor tyrosine kinase (protein tyrosine kinase, PTK)

Properties

COMPARTMENT: plasma membrane STATE: active state MOTIF: ligand-binding site transmembrane domain Tyr phosphorylation site kinase domain MOTIF: ATP-binding site NAME: ATP-binding site