epidermal retinal dehydrogenase 2; RDH-E2; EPHD-2; retinal short chain dehydrogenase reductase 2; retSDR2 (RDHE2, SDR16C5)

Structure: - belongs to the short-chain dehydrogenases/reductases (SDR) family Compartment: membrane (putative) Alternative splicing: named isoforms=2 Expression: - detected in adult lung - detected at low levels in adult brain, heart, testis, placenta, cervix, pancreas, uterus, stomach, rectum, small intestine, colon, esophagus, thymus, skin, & skin keratinocyte - detected in fetal kidney, skin & lung Pathology: - expression is higher in psoriasis lesions relative to unaffected skin from psoriasis patients

General

dehydrogenase membrane protein

Properties

SIZE: entity length = 309 aa MW = 34 kD COMPARTMENT: cellular membrane MOTIF: transmembrane domain {11-31} cofactor-binding site [44-68] COFACTOR-BOUND: NADP binding site SITE: 177-177 FOR-BINDING-OF: Substrate tyrosine residue {Y190} transmembrane domain {270-290}

Database Correlations

UniProt Q8N3Y7 Pfam PF00106 ENZYME 1.1.1.-

References

UniProt :accession Q8N3Y7