REST corepressor 1 (protein CoREST, RCOR1, KIAA0071, RCOR)

Function: 1) component of the BHC complex 2) in the BHC complex, RCOR1 recruits MeCP2 & SUV39H1 3) role in demethylation of Lys-4 of histone H3 by promoting demethylase activity of AOF2/LSD1 on core histones & nucleosomal substrates 4) protects AOF2/LSD1 from the proteasome 5) SANT domains may bridge the nucleosomal substrates & the demethylase AOF2/LSD1 Structure: 1) belongs to the CoREST family 2) contains 1 ELM2 domain 3) contains 2 SANT domains Pathology: - interacts directly with herpes virus HSV-1 ICP0 protein, leading to the disruption of the BHC complex, thereby preventing the BHC complex from repressing transcription of viral genes - upon infection by HSV-1, partially translocated into cytoplasm - phosphorylated by HSV-1 protein kinases Compartment: nucleus Expression: ubiquitously expressed

Properties

SIZE: MW = 53 kD entity length = 482 aa COMPARTMENT: cytoplasm cell nucleus MOTIF: alanine-rich region {18-74} MOTIF: alanine residue (SEVERAL) interaction with HDAC1 {75-254} MOTIF: ELM2 {100-186} SANT 1 {188-236} coiled coil {241-270} MOTIF: Ser phosphorylation site {S257} interaction with LSD1 {293-381} MOTIF: coiled coil {331-366} SANT 2 {379-427}

Database Correlations

OMIM 607675 UniProt Q9UKL0 PFAM correlations

References

UniProt :accession Q9UKL0