heterogeneous nuclear ribonucleoprotein G; hnRNP G; RNA-binding motif protein, X chromosome; glycoprotein p43; contains: heterogeneous nuclear ribonucleoprotein G, N-terminally processed (RBMX, HNRPG, RBMXP1)

Function: - RNA-binding protein - may be involved in pre-mRNA splicing - Arg-185 is dimethylated, probably to asymmetric dimethylarginine - cleavage of initiator Met is partial - if Met-1 is not removed, it is acetylated - if it is removed, Val-2 is acetylated - identified in the spliceosome C complex - component of ribonucleosomes - interacts with KHDRBS3 Structure: - O-glycosylated - contains 1 RRM domain (RNA recognition motif) Compartment: nucleus

General

glycoprotein heterogeneous nuclear ribonucleoprotein (hnRNP) phosphoprotein RNA-binding protein

Properties

SIZE: entity length = 391 aa MW = 42 kD COMPARTMENT: cell nucleus MOTIF: acetylation site SITE: N-TERMINUS EFFECTOR-BOUND: acetyl RNP motif NAME: RNP motif SITE: 8-86 FOR-BINDING-OF: ribonucleic acid MOTIF: ribonucleoprotein-1 motif NAME: ribonucleoprotein-1 motif FOR-BINDING-OF: ribonucleic acid MOTIF: ribonucleoprotein-1 motif ribonucleoprotein-2 motif ribonucleoprotein-2 motif FOR-BINDING-OF: ribonucleic acid MOTIF: ribonucleoprotein-1 motif ribonucleoprotein-2 motif Ser phosphorylation site {S58} Ser phosphorylation site {S88} Ser phosphorylation site {S165} Ser phosphorylation site {S208} Ser phosphorylation site {S277} Ser phosphorylation site {S280} Ser phosphorylation site {S326} Tyr phosphorylation site {Y327} Ser phosphorylation site {S329} Ser phosphorylation site {S330} Ser phosphorylation site {S332} Ser phosphorylation site {S352}

Database Correlations

OMIM 300199 UniProt P38159 PFAM correlations Entrez Gene 27316 Kegg hsa:27316

References

UniProt :accession P38159