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RNA-binding protein 5; RNA-binding motif protein 5; tumor suppressor LUCA15; protein G15; renal carcinoma antigen NY-REN-9 (RBM5)

Function: - component of the spliceosome A complex - regulates alternative splicing of a number of mRNAs - may modulate splice site pairing after recruitment of the U1 & U2 snRNPs to the 5' & 3' splice sites of the intron - may both positively & negatively regulate apoptosis by regulating alternative splicing of several genes involved in this process, including FAS & CASP2/caspase-2 - in the case of FAS, promotes exclusion of exon 6 thereby producing a soluble form of FAS that inhibits apoptosis - in the case of CASP2/caspase-2, promotes exclusion of exon 9 thereby producing a catalytically active form of CASP2/Caspase-2 that induces apoptosis - appears to dissociate from the spliceosome upon formation of the spliceosome B complex - interacts with U2AF2; interaction is direct - interacts with ACIN1, PRPF8, SFRS3, SNRPB, SNRPN, SNRNP70 & SNRNP200; interactions may be indirect Structure: - belongs to the RBM5/RBM10 family - contains 1 C2H2-type Zn+2 finger - contains 1 G-patch domain - contains 1 RanBP2-type Zn+2 finger - contains 2 RRM domain (RNA recognition motif)s Compartment: nucleus Alternative splicing: named isoforms=5 Expression: - isoform 5 is widely expressed in normal tissues & is expressed at increased levels in T-cell leukemia cell lines

General

nuclear protein phosphoprotein RNA-binding motif protein zinc finger protein

Properties

SIZE: entity length = 815 aa MW = 92 kD COMPARTMENT: cell nucleus MOTIF: Ser phosphorylation site {S59} Ser phosphorylation site {S69} Ser phosphorylation site {S78} RNP motif NAME: RNP motif SITE: 98-178 FOR-BINDING-OF: ribonucleic acid MOTIF: ribonucleoprotein-1 motif NAME: ribonucleoprotein-1 motif FOR-BINDING-OF: ribonucleic acid MOTIF: ribonucleoprotein-1 motif ribonucleoprotein-2 motif ribonucleoprotein-2 motif FOR-BINDING-OF: ribonucleic acid MOTIF: ribonucleoprotein-1 motif ribonucleoprotein-2 motif Zinc finger NAME: Zinc finger SITE: 181-210 EFFECTOR-BOUND: Zn+2 RNP motif NAME: RNP motif SITE: 231-315 FOR-BINDING-OF: ribonucleic acid MOTIF: ribonucleoprotein-1 motif NAME: ribonucleoprotein-1 motif FOR-BINDING-OF: ribonucleic acid MOTIF: ribonucleoprotein-1 motif ribonucleoprotein-2 motif ribonucleoprotein-2 motif FOR-BINDING-OF: ribonucleic acid MOTIF: ribonucleoprotein-1 motif ribonucleoprotein-2 motif U2AF2 interaction {321-809} MOTIF: ACIN1, PRPF8 ... {452-535} Ser phosphorylation site {S621} Ser phosphorylation site {S624} Zn finger C2H2-type SITE: 647-677 EFFECTOR-BOUND: Zn+2 Tyr phosphorylation site {Y712} G-patch domain {743-789}

Database Correlations

OMIM 606884 UniProt P52756 PFAM correlations Entrez Gene 10181 Kegg hsa:10181

References

  1. UniProt :accession P52756
  2. Atlas of Genetics & Cytogenetics in Oncology & Haematology http://atlasgeneticsoncology.org/genes/RBM5ID42069ch3p21.html