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histone-binding protein RBBP7; retinoblastoma-binding protein 7; RBBP-7; retinoblastoma-binding protein p46; histone acetyltransferase type B subunit 2; nucleosome-remodeling factor subunit RBAP46 (RBBP7, RBAP46, HAT2)
Function:
- core histone-binding subunit that may target chromatin remodeling factors, histone acetyltransferases & histone deacetylases to their histone substrates (nucleosomal DNA-dependent)
- component of several complexes which regulate chromatin metabolism, including:
a) type B histone acetyltransferase complex
b) histone deacetylase core complex (HDAC)
c) nucleosome remodeling & histone deacetylase complex (NuRD complex)
d) PRC2/EED-EZH2 complex
e) nucleosome remodeling factor complex (NURF complex)
- binds directly to helix 1 of the histone fold of histone H4, a region that is not accessible when H4 is in chromatin
- interacts with the viral protein-binding domain of the retinoblastoma protein (RB1)
- interacts with CREBBP; this interaction may be enhanced by the binding of phosphorylated CREB1 to CREBBP
- interacts with BRCA1, HDAC7 & SUV39H1
Structure:
- belongs to the WD repeat RBAP46/RBAP48/MSI1 family
- contains 6 WD repeats
Compartment: nucleus
Interactions
molecular events
General
phosphoprotein
retinoblastoma-binding protein
WD repeat protein family
Properties
SIZE: entity length = 425 aa
MW = 48 kD
COMPARTMENT: cell nucleus
MOTIF: WD repeat {121-152}
WD repeat {174-205}
WD repeat {224-255}
WD repeat {270-301}
WD repeat {314-345}
Ser phosphorylation site {S354}
WD repeat {371-402}
Ser phosphorylation site {S413}
Thr phosphorylation site {T416}
Database Correlations
OMIM 602922
UniProt Q16576
Pfam PF00400
Entrez Gene 5931
Kegg hsa:5931
References
- UniProt :accession Q16576
- Huang S et al
A cellular protein that competes with SV40 T antigen for
binding to the retinoblastoma gene product.
Nature 350:160 1991
PMID: 2005966
Component-of
histone deacetylase (HDAC) core complex