retinoblastoma-binding protein 5; RBBP-5; retinoblastoma-binding protein RBQ-3 (RBBP5, RBQ3)

Function: - binds preferentially to unphosphorylated Rb protein - component of the SET1 complex - component of MLL-complex - phosphorylated upon DNA damage, probably by ATM or ATR Structure: contains 6 WD repeats Compartment: nucleus Expression: ubiquitously expressed

General

phosphoprotein retinoblastoma-binding protein WD repeat protein family

Properties

SIZE: entity length = 538 aa MW = 59 kD COMPARTMENT: cell nucleus MOTIF: WD repeat {22-63} WD repeat {64-103} WD repeat {148-188} MOTIF: Ser phosphorylation site {S182} Thr phosphorylation site {T193} WD repeat {196-235} WD repeat {249-291} MOTIF: Thr phosphorylation site {T252} WD repeat {293-331} Ser phosphorylation site {S350} Ser phosphorylation site {S388} Ser phosphorylation site {S389} Ser phosphorylation site {S497}

Database Correlations

OMIM 600697 UniProt Q15291 Pfam PF00400 Entrez Gene 5929

References

UniProt :accession Q15291