histone-binding protein RBBP4; retinoblastoma-binding protein 4; RBBP-4; retinoblastoma-binding protein p48; chromatin assembly factor 1 subunit C; CAF-1 subunit C; chromatin assembly factor I p48 subunit; CAF-I 48 kD subunit; CAF-I p48; nucleosome-remodeling factor subunit RBAP48 (RBBP4, RbAp48)

Function: - core histone-binding subunit - may target chromatin assembly factors, chromatin remodeling factors & histone deacetylases to their histone substrates in a manner that is regulated by nucleosomal DNA - component of several complexes which regulate chromatin metabolism a) chromatin assembly factor 1 (CAF-1) b) core histone deacetylase complex (HDAC complex) c) NuRD complex d) PRC2/EED-EZH2 complex e) NURF complex (nucleosome-remodeling factor complex) - component of the DREAM complex (LINC complex) - interacts with SUV39H1 & HDAC7 (putative) - binds directly to helix 1 of the histone fold of histone H4, a region that is not accessible when H4 is in chromatin - interacts with the viral protein-binding domain of the retinoblastoma protein (RB1) - interacts with SPEN/MINT - interacts with BRCA1 - interacts with CREBBP, & this interaction may be enhanced by the binding of phosphorylated CREB1 to CREBBP Structure: - belongs to the WD repeat RBAP46/RBAP48/MSI1 family - contains 6 WD repeats Compartment: nucleus

General

protein subunit retinoblastoma-binding protein WD repeat protein family

Properties

SIZE: entity length = 425 aa MW = 48 kD COMPARTMENT: cell nucleus MOTIF: acetylation site SITE: N-TERMINUS EFFECTOR-BOUND: acetyl WD repeat {122-155} WD repeat {175-206} WD repeat {225-256} WD repeat {271-302} WD repeat {315-346} WD repeat {372-403}

Database Correlations

OMIM 602923 UniProt Q09028 Pfam PF00400 Entrez Gene 5928 Kegg hsa:5928

References

UniProt :accession Q09028