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RB1-inducible coiled-coil protein 1 (RB1CC1, KIAA0203, RBICC)
Function:
1) role in regulation of RB1 expression
2) DNA-binding transcription factor
3) regulates RB1 pathway
4) role in muscular differentiation
5) tumor suppressor
Compartment: nucleus
Expression:
- correlates with expression of RB1
- expression with maturation of osteocytes, chondrocytes, & skeletal muscle cells
Pathology:
- expressed in cultured osteosarcoma cells.
- 20% of primary breast cancers may contain mutations in RB1CC1
General
DNA-binding protein
Properties
SIZE: MW = 183 kD
entity length = 1594 aa
COMPARTMENT: cell nucleus
MOTIF: nuclear translocation signal {566-569}
threonine-rich region {663-666}
MOTIF: threonine residue (SEVERAL)
coiled coil {859-1397}
coiled coil {1438-1485}
Database Correlations
OMIM 606837
UniProt Q8TDY2
References
UniProt :accession Q8TDY2