ribonucleoprotein PTB-binding 1 (protein raver-1, RAVER1, KIAA1978)

Function: - cooperates with PTBP1 to modulate regulated alternative splicing events - promotes exon skipping - cooperates with PTBP1 to modulate switching between mutually exclusive exons during maturation of TPM1 pre-mRNA - interacts with PTBP1, RAVER2, VCL & ACTN1 - component of a complex containing RAVER1, VCL & ACTN1 Structure: contains 3 RRM domains (RNA recognition motif) Compartment: - nucleus, cytoplasm - nuclear, in perinucleolar structures - shuttles between nucleus & cytoplasm - cytoplasm, at focal contacts & cell-cell contacts - associated with myotubes during muscle differentiation Alternative splicing: named isoforms=3

Properties

SIZE: MW = 64 kD entity length = 606 aa COMPARTMENT: cytoplasm cell nucleus MOTIF: Ser phosphorylation site {S14} nuclear translocation signal {45-60} RNP motif NAME: RNP motif SITE: 59-130 FOR-BINDING-OF: ribonucleic acid MOTIF: ribonucleoprotein-1 motif NAME: ribonucleoprotein-1 motif FOR-BINDING-OF: ribonucleic acid MOTIF: ribonucleoprotein-1 motif ribonucleoprotein-2 motif ribonucleoprotein-2 motif FOR-BINDING-OF: ribonucleic acid MOTIF: ribonucleoprotein-1 motif ribonucleoprotein-2 motif RNP motif NAME: RNP motif SITE: 132-210 FOR-BINDING-OF: ribonucleic acid MOTIF: ribonucleoprotein-1 motif NAME: ribonucleoprotein-1 motif FOR-BINDING-OF: ribonucleic acid MOTIF: ribonucleoprotein-1 motif ribonucleoprotein-2 motif ribonucleoprotein-2 motif FOR-BINDING-OF: ribonucleic acid MOTIF: ribonucleoprotein-1 motif ribonucleoprotein-2 motif RNP motif NAME: RNP motif SITE: 221-299 FOR-BINDING-OF: ribonucleic acid MOTIF: ribonucleoprotein-1 motif NAME: ribonucleoprotein-1 motif FOR-BINDING-OF: ribonucleic acid MOTIF: ribonucleoprotein-1 motif ribonucleoprotein-2 motif ribonucleoprotein-2 motif FOR-BINDING-OF: ribonucleic acid MOTIF: ribonucleoprotein-1 motif ribonucleoprotein-2 motif interaction with PTBP1 {307-395} proline-rich region SITE: 406-468 MOTIF: proline residue (SEVERAL) Thr phosphorylation site {T463}

Database Correlations

UniProt Q8IY67 Pfam PF00076

References

UniProt :accession Q8IY67