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RAS & EF-hand domain-containing protein (Ras-related protein Rab-45, RASEF, RAB45)
Function:
- binds predominantly GDP, & also GTP
Structure:
- homodimer
- belongs to the small GTPase superfamily. Rab family
- contains 2 EF-hand domains
Compartment: cytoplasm, perinuclear region
Alternative splicing: named isoforms=2
Expression:
- down-regulated in cutaneous melanoma cells but not in breast cancer cells
General
phosphoprotein
Properties
SIZE: entity length = 740 aa
MW = 83 kD
MOTIF: EF hand
SITE: 8-42
MOTIF: Ca+2-binding site
SITE: 21-32
EF hand
SITE: 42-77
MOTIF: Ca+2-binding site
SITE: 55-66
coiled coil {175-356}
Ser phosphorylation site {S523}
Thr phosphorylation site {T526}
GTP-binding site
SITE: 548-555
GTP-binding site
SITE: 596-600
GTP-binding site
SITE: 654-657
Database Correlations
UniProt Q8IZ41
PFAM correlations
References
UniProt :accession Q8IZ41