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retinoic acid receptor gamma; RAR-gamma; nuclear receptor subfamily 1 group B member 3 (RARG, NR1B3)
Function:
- receptor for retinoic acid
- role in vertebrate development
- retinoic acid is a morphogen & a teratogen
- controls cell function by directly regulating gene expression
- forms a complex with PUS1 & the SRA1 RNA in the nucleus
Structure:
- composed of three domains:
a) modulating N-terminal domain
b) DNA-binding domain
c) C-terminal steroid-binding domain
- belongs to the nuclear hormone receptor family, NR1 subfamily
- contains 1 nuclear receptor DNA-binding domain
Compartment: nucleus
Alternative splicing: named isoforms=2
isoforms differ only in their N-terminal regions
Specific
retinoic acid receptor gamma-1
General
retinoic acid receptor (RAR)
Properties
SIZE: entity length = 454 aa
MW = 50 kD
COMPARTMENT: cell nucleus
MOTIF: Modulating {1-89}
DNA-binding motif
SITE: 90-155
MOTIF: Zn finger C4-type
SITE: 90-110
EFFECTOR-BOUND: Zn+2
Zn finger C4-type
SITE: 126-150
EFFECTOR-BOUND: Zn+2
Hinge {156-201}
binding site
SITE: 202-421
FOR-BINDING-OF: ligand
Database Correlations
OMIM 180190
UniProt P13631
PFAM correlations
Entrez Gene 5916
Kegg hsa:5916
References
- Sporn MB, Roberts AB.
Interactions of retinoids and transforming growth factor-beta
in regulation of cell differentiation and proliferation.
Mol Endocrinol. 1991 Jan;5(1):3-7. Review.
PMID: 2017191
- Green S.
Nuclear hormone receptors. Promiscuous liaisons.
Nature. 1993 Feb 18;361(6413):590-1.
PMID: 8382343
- Wikipedia; Note: retinoic acid receptor entry
http://en.wikipedia.org/wiki/retinoic_acid_receptor
- UniProt :accession P13631