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retinoic acid receptor beta; RAR-beta; nuclear receptor subfamily 1 group B member 2; RAR-epsilon; HBV-activated protein (RARB, HAP, NR1B2)
Function:
- receptor for retinoic acid
- role in vertebrate development
- controls cell function by directly regulating gene expression
Structure:
- composed of three domains:
a) modulating N-terminal domain
b) DNA-binding domain
c) C-terminal steroid-binding domain
- belongs to the nuclear hormone receptor family, NR1 subfamily
- contains 1 nuclear receptor DNA-binding domain
Compartment:
- isoforms beta-1, beta-2: nucleus
- isoform beta-4: cytoplasm
Alternative splicing: named isoforms=4
Specific
retinoic acid receptor beta-1
retinoic acid receptor beta-2
General
retinoic acid receptor (RAR)
Properties
SIZE: entity length = 455 aa
MW = 50 kD
COMPARTMENT: cytoplasm
cell nucleus
MOTIF: Modulating {1-87}
DNA-binding motif
SITE: 88-153
MOTIF: Zn finger C4-type
SITE: 88-108
EFFECTOR-BOUND: Zn+2
Zn finger C4-type
SITE: 124-148
EFFECTOR-BOUND: Zn+2
Hinge {154-199}
binding site
SITE: 200-419
FOR-BINDING-OF: ligand
Database Correlations
OMIM 180220
UniProt P10826
PFAM correlations
Entrez Gene 5915
Kegg hsa:5915
References
- Sporn MB, Roberts AB.
Interactions of retinoids and transforming growth factor-beta
in regulation of cell differentiation and proliferation.
Mol Endocrinol. 1991 Jan;5(1):3-7. Review.
PMID: 2017191
- Green S.
Nuclear hormone receptors. Promiscuous liaisons.
Nature. 1993 Feb 18;361(6413):590-1.
PMID: 8382343
- UniProt :accession P10826