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retinoic acid receptor alpha; RAR-alpha; nuclear receptor subfamily 1 group B member 1 (RARA, NR1B1)
Function:
- receptor for retinoic acid
- role in vertebrate development
- retinoic acid is a morphogen & a teratogen
- controls cell function by directly regulating gene expression
- interacts with CDK7 (putative)
- interacts with NCOA3 & NCOA6 coactivators, leading transcription of target genes
- interacts with NOCA7 (ligand-dependent)
- phosphorylated
- phosphorylation does not change during cell cycle
- phosphorylation on Ser-77 is crucial for transcriptional activity (putative)
Structure:
- composed of three domains:
a) modulating N-terminal domain
b) DNA-binding domain
c) C-terminal steroid-binding domain
- belongs to the nuclear hormone receptor family, NR1 subfamily
- contains 1 nuclear receptor DNA-binding domain
Compartment: nucleus
Alternative splicing: named isoforms=2
Pathology:
- chromosomal aberrations involving RARA may be a cause of acute promyelocytic leukemia
a) translocation t(11;17)(q32;q21) with ZBTB16/PLZF
b) translocation t(15;17)(q24;q21) with PML
c) translocation t(5;17)(q32;q21) with NPM
Related
retinoic acid receptor [RAR]-alpha gene
General
phosphoprotein
retinoic acid receptor (RAR)
zinc finger protein
Properties
SIZE: entity length = 462 aa
MW = 51 kD
COMPARTMENT: cell nucleus
MOTIF: Modulating {1-87}
MOTIF: breakpoint {60-61}
Ser phosphorylation site {S77}
DNA-binding motif
SITE: 88-153
MOTIF: Zn finger C4-type
SITE: 88-108
EFFECTOR-BOUND: Zn+2
Zn finger C4-type
SITE: 124-148
EFFECTOR-BOUND: Zn+2
Hinge {154-199}
binding site
SITE: 200-419
FOR-BINDING-OF: ligand
Ser phosphorylation site {S449}
Ser phosphorylation site {S456}
Ser phosphorylation site {S461}
Database Correlations
OMIM 180240
UniProt P10276
PFAM correlations
Entrez Gene 5914
Kegg hsa:5914
References
- Sporn MB, Roberts AB.
Interactions of retinoids and transforming growth factor-beta
in regulation of cell differentiation and proliferation.
Mol Endocrinol. 1991 Jan;5(1):3-7. Review.
PMID: 2017191
- Green S.
Nuclear hormone receptors. Promiscuous liaisons.
Nature. 1993 Feb 18;361(6413):590-1.
PMID: 8382343
- Atlas of genetics & cytogenetics in oncology & haematology
http://atlasgeneticsoncology.org/genes/RARAID46.html
- Wikipedia; Note: retinoic acid receptor entry
http://en.wikipedia.org/wiki/retinoic_acid_receptor
- UniProt :accession P10276