Search
retinoic acid receptor (RAR)
Function:
- retinoic acid is a morphogen & a teratogen
- binds to DNA as heterodimer with RXR
- cytoplasmic anchoring associated with hsp90
Interactions
molecular events
Related
heat shock protein [hsp]-90
retinoic acid
retinoic acid receptor [RAR] gene
retinoid X receptor (RXR)
Specific
retinoic acid receptor alpha; RAR-alpha; nuclear receptor subfamily 1 group B member 1 (RARA, NR1B1)
retinoic acid receptor beta; RAR-beta; nuclear receptor subfamily 1 group B member 2; RAR-epsilon; HBV-activated protein (RARB, HAP, NR1B2)
retinoic acid receptor gamma; RAR-gamma; nuclear receptor subfamily 1 group B member 3 (RARG, NR1B3)
General
nuclear hormone receptor NR1 subfamily
Properties
COMPARTMENT: cytoplasm
MOTIF: allosteric site
DNA-binding motif
MOTIF: kxffkr
NAME: kxffkr
FOR-BINDING-OF: calreticulin
FORM: kxffkr
Zinc finger
NAME: Zinc finger (2)
EFFECTOR-BOUND: Zn+2
ligand-binding site
FOR-BINDING-OF: retinoic acid
References
- Alberts et al Molecular Biology of the Cell,
2nd ed. 1989, pg 704
- Green S.
Nuclear hormone receptors. Promiscuous liaisons.
Nature. 1993 Feb 18;361(6413):590-1.
PMID: 8382343
Component-of
molecular complex