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rap2A proto-oncogene protein; Ras-related protein rap-2a; RbBP-30 (RAP2A)
Function:
- activated by guanine nucleotide-exchange factors EPAC & EPAC2 (cAMP-dependent)
- activated by MRGEF
- interacts with PLCE1
- interacts with SGSM1, SGSM2, SGSM3 & ARHGAP29
- the GTP-bound form of RAP2A interacts with RUNDC3A
Structure:
- the effector domain mediates the interaction with RUNDC3A
- belongs to the small GTPase superfamily, Ras family
Compartment:
- cell membrane; lipid-anchor; cytoplasmic side (putative)
General
rap2 proto-oncogene protein
Properties
SIZE: entity length = 183 aa
MW = 21 kD
COMPARTMENT: cytoplasm
MOTIF: GTP-binding site
SITE: 10-17
Effector region (Probable) {32-40}
GTP-binding site
SITE: 57-61
GTP-binding site
SITE: 116-119
CaaX motif
SITE: C-TERMINUS
QUALITIES: AAX-TRUNCATED
CARBOXYMETHYLATED
EFFECTOR-BOUND: farnesyl
BOUND-VIA: cysteine residue
Database Correlations
OMIM 179540
UniProt P10114
Pfam PF00071
Entrez Gene 5911
Kegg hsa:5911
References
- UniProt :accession P10114
- Atlas of Genetics & Cytogenetics in Oncology & Haematology
http://atlasgeneticsoncology.org/genes/RAP2AID274.html
- Kahn RA, Der CJ, Bokoch GM.
The ras superfamily of GTP-binding proteins: guidelines on
nomenclature.
FASEB J. 1992 May;6(8):2512-3.
PMID: 1592203